GBR 12935 HCl

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09762CAS号：67469-81-2纯度：98%

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CAS号	67469-81-2	货号	BCP09762
中文名	GBR 12935 HCl
英文名	GBR 12935 HCl
中文别名
英文别名	GBR12935;GBR-12935;
SMILES
化学名称
分子式	C28H36Cl2N2O	分子量	487.5
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine) . Co-perfusion of 100 microM GBR 12909 or GBR 12935 with either 100 microM sulpiride or raclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopamine to basal levels. In vitro, GBR 12909 (1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens . in vivo: GBR 12935 elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg. Locomotor stimulation by GBR 12935 remained consistent in both strains with repeated injections. DBA/2J mice became sensitized to cocaine-induced stereotypy with repeated injections. Cocaine induced no