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| CAS号 | 769917-29-5 | 货号 | BCP48083 |
| 关联产品 | 502656-68-0（CAY10462） | ||
| 中文名 | CAY10434 | ||
| 英文名 | CAY10434 | ||
| 中文别名 | |||
| 英文别名 | CAY 10434;CAY-10434; | ||
| SMILES | CN(C)CCCCCCOC1=CC=C(C=C1)N2C=CN=C2 | ||
| 化学名称 | |||
| 分子式 | C17H25N3O | 分子量 | 287.4 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. Alkylaryl imidazoles have been previously shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis. CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 value of 8.8 nM when tested in human renal microsomes. CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes. | ||
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