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| CAS号 | 81246-85-7 | 货号 | BCP47805 |
| 中文名 | 8,9-Eet | ||
| 英文名 | 8,9-Eet | ||
| 中文别名 | |||
| 英文别名 | (+/-)8,9-EET;8,9-Epoxyeicosatrienoic acid; | ||
| SMILES | CCCCCC=CCC=CCC1C(O1)CC=CCCCC(=O)O | ||
| 化学名称 | |||
| 分子式 | C20H32O3 | 分子量 | 320.47 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats. | ||
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