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CAS号 | 1131456-28-4 | 货号 | BCP46515 |
中文名 | KGP94 | ||
英文名 | KGP94 | ||
中文别名 | |||
英文别名 | KGP 94; KGP-94; | ||
SMILES | C1=CC(=CC(=C1)O)C(=NNC(=S)N)C2=CC(=CC=C2)Br | ||
化学名称 | |||
分子式 | C14H12BrN3OS | 分子量 | 350.23 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. KGP94 inhibits the activity of cathepsin L toward human type I collagen. KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment. |
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