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CAS号 | 88321-09-9 | 货号 | BCP20521 |
中文名 | 阿洛司他丁 | ||
英文名 | Loxistatin | ||
中文别名 | |||
英文别名 | EP453;E-64D;E-64-d;E-64c ethyl ester; Aloxistatin;NSC 694281; NSC694281; NSC-694281;EP-453; EP 453; | ||
SMILES | O=C([C@]1O[C@@H]1C(N[C@](C(NCCC(C)C)=O)CC(C)C)=O)OCC | ||
化学名称 | |||
分子式 | C17H30N2O5 | 分子量 | 342.43 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus. |
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