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| CAS号 | 123318-82-1 | 货号 | BCP23422 |
| 中文名 | 氯法拉滨 | ||
| 英文名 | Clofarabine | ||
| 中文别名 | 克罗拉滨; | ||
| 英文别名 | C1-F-Ara-A;Clolar;Evoltra;Clofarex; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C10H11ClFN5O3 | 分子量 | 303.68 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. | ||
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