ARQ092盐酸盐 新
参考资料
仅供科学研究，不可用于个人用途。
| 规格 | 价格(CNY) | 是否现货 | 购买咨询 |
|---|---|---|---|
| 10.00 mg | ￥950.00 | In-stock | 购买咨询 |
| 25.00 mg | ￥1750.00 | In-stock | 购买咨询 |
| 50.00 mg | ￥2800.00 | In-stock | 购买咨询 |
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| CAS号 | 1313883-00-9 | 货号 | BCP25709 |
| 中文名 | ARQ092盐酸盐 | ||
| 英文名 | Miransertib HCl | ||
| 中文别名 | Miransertib盐酸盐; | ||
| 英文别名 | Miransertib hydrochloride; ARQ092 HCl; ARQ-092 HCl; ARQ 092 HCl; | ||
| SMILES | C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N.Cl | ||
| 化学名称 | |||
| 分子式 | C27H25ClN6 | 分子量 | 468.99 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma. | ||
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