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| CAS号 | 138794-73-7 | 货号 | BCP29424 |
| 中文名 | Sardomozide dihydrochloride | ||
| 英文名 | Sardomozide dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | CGP 48664A;CGP-48664A;CGP48664A; | ||
| SMILES | NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.[H]Cl.[H]Cl | ||
| 化学名称 | |||
| 分子式 | C11H16Cl2N6 | 分子量 | 303.19 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Sardomozide dihydrochloride, also known as CGP48664A, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. | ||
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