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SH-4-54 结构式

SH-4-54

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货号 :BCP28211CAS号 :1456632-40-8纯度:98%
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  • 基本信息与产品描述
CAS号 1456632-40-8 货号 BCP28211
中文名 SH-4-54
英文名 SH-4-54
中文别名
英文别名 SH 4-54; SH4-54; SH-454; SH 454; SH454;
SMILES O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1
化学名称
分子式 C29H27F5N2O5S 分子量 621.17
纯度 98% 配送 惯例下常温包邮
产品描述 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations. Moreover, in vivo,SH-4-54 exhibited blood-brain barrier permeability, potently controlled glioma tumor growth, and inhibited pSTAT3 in vivo.
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