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CAS号 | 1802220-02-5 | 货号 | BCP19778 |
中文名 | 洛普替尼 | ||
英文名 | Repotrectinib | ||
中文别名 | |||
英文别名 | TPX-0005;TPX 0005; TPX0005; | ||
SMILES | CC1CNC(=O)C2=C3N=C(C=CN3N=C2)NC(C4=C(O1)C=CC(=C4)F)C | ||
化学名称 | |||
分子式 | C18H18FN5O2 | 分子量 | 355.37 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.TPX-0005 is a Src/FAK/Janus kinase 2 (JAK2) inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing. |
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