ANA-12

参考资料仅供科学研究，不可用于个人用途。

货号：BCP16021CAS号：219766-25-3纯度：98%

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CAS号	219766-25-3	货号	BCP16021
中文名	ANA-12
英文名	ANA-12
中文别名
英文别名	ANA12;ANA 12;
SMILES
化学名称
分子式	C22H21N3O3S	分子量	407.49
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM [1]. The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine. in vivo: Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans [1]. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats.