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| CAS号 | 1919868-83-9 | 货号 | BCP30585 |
| 中文名 | LOXO-101 HCl salt | ||
| 英文名 | LOXO-101 HCl salt | ||
| 中文别名 | |||
| 英文别名 | LOXO101 HCl salt；LOXO 101 HCl salt；Larotrectinib HCl;LOXO-101 Hydrochloric; | ||
| SMILES | C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F | ||
| 化学名称 | |||
| 分子式 | C21H23ClF2N6O2 | 分子量 | 464.90 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LOXO-101 is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. | ||
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