Pulrodemstat 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44101CAS号：1821307-10-1纯度：98%

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CAS号	1821307-10-1	货号	BCP44101
中文名	Pulrodemstat
英文名	Pulrodemstat
中文别名
英文别名	CC-90011; CC 90011; CC90011; Pulrodemstatum;
SMILES	CN1C(=O)C(=C(N=C1N2CCC(CC2)N)C3=CC(=C(C=C3)C#N)F)C4=CC(=C(C=C4)OC)F
化学名称
分子式	C24H23F2N5O2	分子量	451.47
纯度	98%	配送	惯例下常温包邮
产品描述	Pulrodemstat is an orally available inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, pulrodemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor (remove hyphen) suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family that is overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.