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CAS号 | 2410512-38-6 | 货号 | BCP44757 |
中文名 | JQKD-82 | ||
英文名 | JQKD-82 | ||
中文别名 | |||
英文别名 | JQKD82; JQKD 82; PCK82; PCK-82; PCK 82;JADA82; | ||
SMILES | CCN(CCN(C)C)C(=O)CNCC1=NC=CC(=C1)C(=O)OC2=C(C=C(C=C2)OC(C)C)OC(C)C | ||
化学名称 | |||
分子式 | C27H40N4O5 | 分子量 | 500.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently |
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