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CAS号 | 1846570-31-7 | 货号 | BCP32745 |
中文名 | CM-272 | ||
英文名 | CM-272 | ||
中文别名 | |||
英文别名 | CM 272; CM272; | ||
SMILES | CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5 | ||
化学名称 | |||
分子式 | C28H38N4O3 | 分子量 | 478.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. Anti-tumour Activity. |
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