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CAS号 | 2088113-98-6 | 货号 | BCP29471 |
中文名 | AZ-31 | ||
英文名 | AZ-31 | ||
中文别名 | |||
英文别名 | AZ31;AZ 31; | ||
SMILES | |||
化学名称 | |||
分子式 | C24H28N4O3 | 分子量 | 420.513 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AZ-31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM; displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR; reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice; showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. |
Tags:AZ-31 供应商,AZ-31 购买,AZ-31 生产,AZ-31 批量,AZ-31 供应,AZ-31 订购,AZ-31 采购