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| CAS号 | 896705-16-1 | 货号 | BCP13273 |
| 中文名 | Bmh-21 | ||
| 英文名 | Bmh-21 | ||
| 中文别名 | |||
| 英文别名 | Bmh 21;Bmh21; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C21H20N4O2 | 分子量 | 360.16 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH-21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress. The findings also show that interference with DNA and DNA metabolic processes can be exploited therapeutically without causing DNA damage. | ||
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