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| CAS号 | 2089288-03-7 | 货号 | BCP28994 |
| 中文名 | AZD1390 | ||
| 英文名 | AZD1390 | ||
| 中文别名 | |||
| 英文别名 | AZD-1390; AZD 1390; | ||
| SMILES | O=C(N1C(C)C)N(C)C2=C1C3=CC(C4=CC=C (OCCCN5CCCCC5)N=C4)=C(F)C=C3N=C2 | ||
| 化学名称 | |||
| 分子式 | C27H32FN5O2 | 分子量 | 477.58 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AZD1390 is a potent and selective ATM inhibitor with the ability to cross the blood-brain barrier suitable for the treatment of intracranial malignancies.AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50 = 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies. | ||
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Tags:AZD1390 供应商,AZD1390 购买,AZD1390 生产,AZD1390 批量,AZD1390 供应,AZD1390 订购,AZD1390 采购