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Cyano Temozolomide 结构式

氰基替莫唑胺

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货号 :BCP22927CAS号 :287964-59-4纯度:98%
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  • 基本信息与产品描述
CAS号 287964-59-4 货号 BCP22927
中文名 氰基替莫唑胺
英文名 Cyano Temozolomide
中文别名
英文别名 Cyanotemozolomide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile;
SMILES C1=NC(=C2N1C(=O)C(=NN2)[N+](=O)[O-])C(=O)N
化学名称
分子式 C6H4N6O 分子量 224.13
纯度 98% 配送 惯例下常温包邮
产品描述 Temozolomide is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system.
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