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| CAS号 | 287964-59-4 | 货号 | BCP22927 |
| 中文名 | 氰基替莫唑胺 | ||
| 英文名 | Cyano Temozolomide | ||
| 中文别名 | |||
| 英文别名 | Cyanotemozolomide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile; | ||
| SMILES | C1=NC(=C2N1C(=O)C(=NN2)[N+](=O)[O-])C(=O)N | ||
| 化学名称 | |||
| 分子式 | C6H4N6O | 分子量 | 224.13 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Temozolomide is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. | ||
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