Poloxin 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP45204CAS号：321688-88-4纯度：98%

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CAS号	321688-88-4	货号	BCP45204
中文名	Poloxin
英文名	Poloxin
中文别名
英文别名
SMILES	CC =CC=CC=C1C(=O)
化学名称
分子式	C18H19NO3	分子量	297.35
纯度	98%	配送	惯例下常温包邮
产品描述	Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD. Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis. More important, we report, for the first time to our knowledge, that the PBD inhibitor, Poloxin , significantly suppresses tumor growth of cancer cell lines in xenograft mouse models by lowering the proliferation rate and triggering apoptosis in treated tumor tissues.