氯尼达明

参考资料仅供科学研究，不可用于个人用途。

货号：BCP06555CAS号：50264-69-2纯度：98%

在线咨询

购买咨询

全国免运费！免费咨询：400-099-8200 或手机联系：13472751340

* 必填项

请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS号	50264-69-2	货号	BCP06555
中文名	氯尼达明
英文名	Lonidamine
中文别名
英文别名	DICA;Diclondazolic Acid;AF1890;AF 1890;AF-1890;
SMILES
化学名称
分子式	C15H10Cl2N2O2	分子量	321.16
纯度	98%	配送	惯例下常温包邮
产品描述	Lonidamine inhibits glycolysis by the inactivation of hexokinase. Interestingly, Lonidamine seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP. In addition, lonidamine may increase programmed cell death. This stems from the observation that mitochondria and mitochondria-bound hexokinase are crucial for induction of apoptosis. In vitro models with lonidamine exhibit the hallmarks of apoptosis, including mitochondrial membrane depolarization, release of cytochrome C, phosphatidylserine externalization, and DNA fragmentation. Lonidamine also blocks CFTR Cl- channels in vitro.