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| CAS号 | 3031789-26-8 | 货号 | BCP49658 |
| 中文名 | ZK53 | ||
| 英文名 | ZK53 | ||
| 中文别名 | |||
| 英文别名 | ZK 53;ZK-53;1-Piperazinecarboxamide, N-[(4-bromophenyl)methyl]-4-[(3,5-difluorophenyl)methyl]-; | ||
| SMILES | C1CN(CCN1CC2=CC(=CC(=C2)F)F)C(=O)NCC3=CC=C(C=C3)Br | ||
| 化学名称 | |||
| 分子式 | C19H20BrF2N3O | 分子量 | 424.28 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model. | ||
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