陶扎色替新

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货号：BCP01859CAS号：639089-54-6纯度：98%

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CAS号	639089-54-6	货号	BCP01859
中文名	陶扎色替
英文名	Tozasertib
中文别名
英文别名	VX680;MK-0457;VX-680;MK0457;VX 680;MK 0457;
SMILES	CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C
化学名称
分子式	C23H28N8OS	分子量	464.6
纯度	98%	配送	惯例下常温包邮
产品描述	The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 µM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase.

陶扎色替 新