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| CAS号 | 68489-09-8 | 货号 | BCP43788 |
| 中文名 | WS-12 | ||
| 英文名 | WS-12 | ||
| 中文别名 | |||
| 英文别名 | WS 12; WS12; | ||
| SMILES | CC1CCC(C(C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C | ||
| 化学名称 | |||
| 分子式 | C18H27NO2 | 分子量 | 289.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). WS-12 robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM) thereby displaying a higher potency and efficacy compared to menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer. | ||
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