Rosiptor acetate 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24919CAS号：782487-29-0纯度：98%

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CAS号	782487-29-0	货号	BCP24919
关联产品	782487-28-9（Rosiptor）
中文名	Rosiptor acetate
英文名	Rosiptor acetate
中文别名
英文别名	AQX-1125 acetate;AQX1125 acetate;AQX 1125 acetate;
SMILES	CC(=O)O.CC1(CCC(CC1CO)O)C2CCC3(C(C2CN)CCC3=C)C
化学名称
分子式	C22H39NO4	分子量	381.56
纯度	98%	配送	惯例下常温包邮
产品描述	Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.