ABT-737

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01725CAS号：852808-04-9纯度：98%

规格	价格(CNY)	是否现货	购买咨询
50.00 mg	￥1850.00	In-stock	购买咨询
100.00 mg	￥2500.00	In-stock	购买咨询

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CAS号	852808-04-9	货号	BCP01725
中文名	ABT-737
英文名	ABT-737
中文别名
英文别名	ABT737;ABT 737;
SMILES	CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
化学名称
分子式	C42H45ClN6O5S2	分子量	813.43
纯度	98%	配送	惯例下常温包邮
产品描述	ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM, 80 nM and 80 nM, respectively. ABT-737 induces apoptosis in HL60 cells, which due to decreased Bcl-2/Bax heterodimerization and has no effect on cell cycle distribution. ABT-737 also induces cytochrome c release from purified mitochondria and promotes conformational changes in Bax that are associated with apoptosis. Resistant cells (Hela and MCF-7) can be sensitized to ABT-737 by approaches that down-regulate, destabilize, or inactivate Mcl-1. ABT-737 also causes Bax/BAK-dependent cytochrome c release only when Mcl-1 has been neutralized. ABT-737 displaces Bim from Bcl2's BH3-binding pocket, allowing Bim to activate Bax, induce mitochondrial permeabilization, and rapidly commit the primary chronic lymphocytic leukemia (CLL) cells to death. Knockdown of Mcl-1 with siRNA sensitizes two resistant SCLC cell lines H196 and DMS114 to ABT-737 by enhancing