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| CAS号 | 2180923-05-9 | 货号 | BCP47569 |
| 中文名 | Lisaftoclax | ||
| 英文名 | Lisaftoclax | ||
| 中文别名 | |||
| 英文别名 | APG-2575;APG2575;APG 2575;Bcl-2/Bcl-xl inhibitor 1; | ||
| SMILES | C1CC2(C1)CCC(=C(C2)C3=CC=C(C=C3)Cl)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)NS(=O)(=O)C6=CC(=C(C=C6)NCC7COCCO7)[N+](=O)[O-])OC8=CN=C9C(=C8)C=CN9 | ||
| 化学名称 | |||
| 分子式 | C45H48ClN7O8S | 分子量 | 882.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Lisaftoclax is an orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. | ||
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