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瀚香生物(Biochempartner)的GDC-0941被文献引用
| CAS号 | 957054-30-7 | 货号 | BCP01714 |
| 中文名 | GDC-0941 | ||
| 英文名 | GDC-0941 | ||
| 中文别名 | |||
| 英文别名 | GDC 0941;GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib; Pictilisib; | ||
| SMILES | CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6 | ||
| 化学名称 | |||
| 分子式 | C23H27N7O3S2 | 分子量 | 513.64 |
| 纯度 | 99% | 配送 | 惯例下常温包邮 |
| 产品描述 | Pictilisib is a small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. | ||
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