Saridegib hydrochloride

参考资料仅供科学研究，不可用于个人用途。

货号：BCP21080CAS号：1169829-40-6纯度：98%

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CAS号	1169829-40-6	货号	BCP21080
中文名	Saridegib hydrochloride
英文名	Saridegib hydrochloride
中文别名
英文别名	Saridegib HCl;IPI 926 hydrochloride;IPI 926; IPI-926; IPI926; Saridegib; Patidegip;
SMILES	CC1=C(C[C@@]2([H])[C@@]3([H])CC[C@@]4([H])[C@]2(C)CC[C@@H](NS(C)(=O)=O)C4)[C@@]3([H])CC[C@@]([C@@H]5C)(C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6.Cl[H]
化学名称
分子式	C29H48N2O3S.HCl	分子量	541.23
纯度	98%	配送	惯例下常温包邮
产品描述	Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.