HPI-4

参考资料仅供科学研究，不可用于个人用途。

货号：BCP18834CAS号：302803-72-1纯度：98%

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CAS号	302803-72-1	货号	BCP18834
中文名	HPI-4
英文名	HPI-4
中文别名
英文别名	CiliobrevinA;HPI 4;HPI4;Hedgehog Pathway Inhibitor 4;
SMILES
化学名称
分子式	C17H9Cl2N3O2	分子量	358.18
纯度	98%	配送	惯例下常温包邮
产品描述	Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.