瑞卡帕布樟磺酸盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP25678CAS号：1327258-57-0纯度：99%

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CAS号	1327258-57-0	货号	BCP25678
中文名	瑞卡帕布樟磺酸盐
英文名	Rucaparib camsylate
中文别名
英文别名
SMILES	CC1(C2CCC1(C(=O)C2)CS(=O)(=O)O)C.CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
化学名称
分子式	C29H34FN3O5S	分子量	555.66
纯度	99%	配送	惯例下常温包邮
产品描述	Rucaparib Camsylate is the camsylate salt form of rucaparib, an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types.

瑞卡帕布樟磺酸盐 新