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| CAS号 | 2360851-29-0 | 货号 | BCP42877 |
| 中文名 | RBN012759 | ||
| 英文名 | RBN012759 | ||
| 中文别名 | |||
| 英文别名 | RBN-012759; RBN 012759; | ||
| SMILES | C1CC1COC2=CC3=C(C(=C2)F)C(=O)NC(=N3)CSC4CCC(CC4)O | ||
| 化学名称 | |||
| 分子式 | C19H23FN2O3S | 分子量 | 378.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RBN012759 is a potent and selective PARP14 inhibitor which decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants. RBN012759 inhibits PARP14 with a biochemical half-maximal inhibitory concentration of 0.003 μM, exhibits >300-fold selectivity over all PARP family members, and its profile enables further study of PARP14 biology and disease association both in vitro and in vivo. Inhibition of PARP14 with RBN012759 reverses IL-4-driven protumor gene expression in macrophages and induces an inflammatory mRNA signature similar to that induced by immune checkpoint inhibitor therapy in primary human tumor explants. | ||
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