他拉唑帕尼甲苯磺酸盐新

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货号：BCP29084CAS号：1373431-65-2纯度：98%

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CAS号	1373431-65-2	货号	BCP29084
中文名	他拉唑帕尼甲苯磺酸盐
英文名	Talazoparib tosylate
中文别名
英文别名	BMN 673ts;BMN-673ts;BMN673ts;BMN673; BMN673; BMN-673; LT673; LT 673; LT-673; MDV-3800; MDV 3800; MDV3800;
SMILES	O=C1NN=C2C3=C1C=C(F)C=C3N[C@](C4=CC=C(F)C=C4)[C@]2C5=NC=NN5C.O=S(C6=CC=C(C)C=C6)(O)=O
化学名称
分子式	C26H22F2N6O4S	分子量	552.55
纯度	98%	配送	惯例下常温包邮
产品描述	Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

他拉唑帕尼甲苯磺酸盐 新