NSC 133723 热促

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02884CAS号：19741-14-1纯度：98%

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CAS号	19741-14-1	货号	BCP02884
中文名	NSC 133723
英文名	NSC 133723
中文别名	4-氨基-4-脱氧-10-甲基蝶酸;
英文别名	NSC131463;DAMPA;NSC-131463;Deoxyaminopteroic acid;Methotrexate Impurity E;4-Amino-4-deoxy-10-methylpteroic acid;
SMILES	O=C(O)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1
化学名称
分子式	C15H15N7O2	分子量	325.33
纯度	98%	配送	惯例下常温包邮
产品描述	NSC 131463 is a minor metabolite of methotrexate. It inhibited L1210 cell proliferation in culture (IC50 = 0.3 μM), and prolonged the survival of L1210 leukemic mice (98% increase in lifespan at 120 mg/kg, qdx9). Studies on the interaction of mAPA-HCysA with partially purified mouse liver folyl polyglutamate synthetase revealed that mAPA-HCysA was not a substrate. Hence, the increased dose of mAPA-HCysA required to inhibit tumor growth in vitro and in vivo relative to methotrexate may reflect, in part, the inability of this compound to form non-effluxing polyglutamates.

NSC 133723 热 促