甲氨蝶呤

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货号：BCP02078CAS号：59-05-2纯度：98%

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CAS号	59-05-2	货号	BCP02078
中文名	甲氨蝶呤
英文名	Abitrexate
中文别名
英文别名	Methotrexate；Amethopterin; CL14377; WR19039；CL-14377; WR-19039；CL 14377; WR 19039;
SMILES
化学名称
分子式	C20H22N8O5	分子量	454.44
纯度	98%	配送	惯例下常温包邮
产品描述	Methotrexate (0.1-10 mM) induces apoptosis of in vitro activated T cells from human peripheral blood. Methotrexate achieves clonal deletion of activated T cells in mixed lymphocyte reactions. Methotrexate can selectively delete activated peripheral blood T cells by a CD95-independent pathway. Methotrexate is taken up by cells via the reduced folate carrier and then is converted within the cells to polyglutamates. Methotrexate leads to diminished production of leukotriene B4 by neutrophils stimulated ex vivo. Methotrexate polyglutamates inhibit the enzyme aminoimidazolecarboxamidoadenosineribonucleotide (AICAR) transformylase more potently than the other enzymes involved in purine biosynthesis. Methotrexate is also known to suppress TNF activity by suppressing TNF-induced nuclear factor-κB activation in vitro, in part related to a reduction in the degradation and inactivation of an inhibitor of this factor, IκBα, and probably related to the release of adenosine. Methotrexate suppresses