Terameprocol 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24515CAS号：24150-24-1纯度：98%

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CAS号	24150-24-1	货号	BCP24515
中文名	Terameprocol
英文名	Terameprocol
中文别名
英文别名	EM1421; EM-1421; EM 1421; tetramethyl-NDGA; tetra-O-methyl nordihydroguaiaretic acid;
SMILES	CC(CC1=CC(=C(C=C1)OC)OC)C(C)CC2=CC(=C(C=C2)OC)OC
化学名称
分子式	C22H30O4	分子量	358.47
纯度	98%	配送	惯例下常温包邮
产品描述	Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In virally-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular endothelial growth factor (VEGF), which are overexpressed in a variety of cancers. By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis.