去甲二氢愈创木酸

参考资料仅供科学研究，不可用于个人用途。

货号：BCP08590CAS号：500-38-9纯度：98%

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CAS号	500-38-9	货号	BCP08590
中文名	去甲二氢愈创木酸
英文名	Nordihydroguaiaretic acid
中文别名
英文别名	NDGA;Masoprocol;
SMILES	CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2
化学名称
分子式	C18H22O4	分子量	302.36
纯度	98%	配送	惯例下常温包邮
产品描述	Nordihydroguaiaretic acid, also known as NDGA, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase.