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| CAS号 | 2765081-21-6 | 货号 | BCP49648 |
| 中文名 | RAS-IN-2 | ||
| 英文名 | RAS-IN-2 | ||
| 中文别名 | |||
| 英文别名 | RMC6236;RMC 6236;RMC-6236;RAS Inhibitor A122; | ||
| SMILES | CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C)C(C)OC)(C)C)NC(=O)C8CC8C | ||
| 化学名称 | |||
| 分子式 | C44H58N8O5S | 分子量 | 811.06 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RAS-IN-2 (RMC-6236) is an orally bioavailable pan-RAS inhibitor. RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor cells in which RAS is overexpressed and/or mutated. | ||
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