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| CAS号 | 2851885-95-3 | 货号 | BCP49670 |
| 中文名 | ARV393 | ||
| 英文名 | ARV393 | ||
| 中文别名 | |||
| 英文别名 | ARV-393;ARV 393; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C46H53ClFN9O7 | 分子量 | 898.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma. | ||
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