BMS299897

参考资料仅供科学研究，不可用于个人用途。

货号：BCP06241CAS号：290315-45-6纯度：98%

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CAS号	290315-45-6	货号	BCP06241
中文名	BMS299897
英文名	BMS299897
中文别名
英文别名	BMS 299897;BMS-299897;
SMILES
化学名称
分子式	C24H21ClF3NO4S	分子量	511.94
纯度	98%	配送	惯例下常温包邮
产品描述	BMS 299897 is a selective inhibitor for gamma-secretase. Reductions in the formation of Abeta peptides by gamma-secretase inhibitors may be a viable therapy for reducing Abeta in Alzheimer's disease. BMS-299897 is a gamma-secretase inhibitor that was effective in reducing amyloid beta-peptide (A beta) in transgenic mice and guinea pigs. in vitro: BMS-299897 dose-dependently increased brain concentrations of APP carboxy-terminal fragments, consistent with inhibition of gamma-secretase. BMS-299897 (100 mg/kg po) reduced brain and plasma Abeta(1-40) rapidly (within 20min) and maximally within 3 h. BMS-299897 dose-dependently reduced cortical, cerebrospinal fluid (CSF), and plasma Abeta in guinea pigs with ED(50) values of 30 mg/kg intraperitoneally, without affecting CSF levels of alpha-sAPP. The reductions in cortical Abeta correlated significantly with the reductions in both plasma (r(2) = 0.77) and CSF (r(2) = 0.61) Abeta . in vivo: BMS-299897blocked the Aβ(25-35)-induced deficits in s