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CAS号 | 3690-10-6 | 货号 | BCP12209 |
中文名 | 扎布拉林 | ||
英文名 | Zebularine | ||
中文别名 | 2-嘧啶酮-B-核甙; | ||
英文别名 | NSC309132;NSC-309132;NSC 309132;4-Deoxyuridine; | ||
SMILES | C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O | ||
化学名称 | |||
分子式 | C9H12N2O5 | 分子量 | 228.2 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Zebularine is a synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. |
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