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Zebularine 结构式

扎布拉林

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货号 :BCP12209CAS号 :3690-10-6纯度:98%
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  • 基本信息与产品描述
CAS号 3690-10-6 货号 BCP12209
中文名 扎布拉林
英文名 Zebularine
中文别名 2-嘧啶酮-B-核甙;
英文别名 NSC309132;NSC-309132;NSC 309132;4-Deoxyuridine;
SMILES C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O
化学名称
分子式 C9H12N2O5 分子量 228.2
纯度 98% 配送 惯例下常温包邮
产品描述 Zebularine is a synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.
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