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LXR623 结构式

LXR623

参考资料 仅供科学研究，不可用于个人用途。
货号 ：BCP03659CAS号 ：875787-07-8纯度：97%
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  • 基本信息与产品描述
CAS号 875787-07-8 货号 BCP03659
中文名 LXR623
英文名 LXR623
中文别名
英文别名 LXR-623;LXR 623;WAY-252623;WAY252623;WAY 252623;
SMILES ClC1=C(CN2N=C(C(C(F)(F)F)=CC=C3)C3=C2C4=CC=C(F)C=C4)C=CC(F)=C1
化学名称
分子式 C21H12ClF5N2 分子量 422.78
纯度 97% 配送 惯例下常温包邮
产品描述 LXR623, also known as WAY-252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR(-/-) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significantly reduced total (50-55%) and LDL-cholesterol (LDLc) (70-77%) in a time- and dose-dependent manner as well as increased expression of the target genes ABCA1/G1 in peripheral blood cells.
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