BMS-779788

参考资料仅供科学研究，不可用于个人用途。

货号：BCP20751CAS号：918348-67-1纯度：98%

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CAS号	918348-67-1	货号	BCP20751
中文名	BMS-779788
英文名	BMS-779788
中文别名
英文别名	BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652;
SMILES	OC(C)(C)C1=CN(C2=CC=C(C3=CC=CC(S(=O)(C)=O)=C3)C=C2)C(C(C)(C4=CC=CC=C4Cl)C)=N1
化学名称
分子式	C28H29ClN2O3S	分子量	509.06
纯度	98%	配送	惯例下常温包邮
产品描述	BMS-779788, also known as XL-652, EXEL 04286652 and BMS-788, is potent partial LXR agonist with LXRβ selectivity, which has an improved therapeutic window in the cynomolgus monkey compared with a full pan agonist. BMS-779788 induced LXR target genes in blood in vivo with an EC50 = 610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 was 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B.