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Cerdulatinib HCl salt 结构式

赛度替尼盐酸盐

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货号 :BCP25893CAS号 :1369761-01-2纯度:98%
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  • 基本信息与产品描述
CAS号 1369761-01-2 货号 BCP25893
中文名 赛度替尼盐酸盐
英文名 Cerdulatinib HCl salt
中文别名 CERDULATINIB 盐酸盐;
英文别名 Cerdulatinib HCl;PRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070; Cerdulatinib;
SMILES
化学名称
分子式 C20H28ClN7O3S 分子量 482
纯度 98% 配送 惯例下常温包邮
产品描述 Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Â’s within the range of 0.11μM to 0.57μM. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations.
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