PRT062607 HCl

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09980CAS号：1370261-97-4纯度：98%

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CAS号	1370261-97-4	货号	BCP09980
中文名	PRT062607 HCl
英文名	PRT062607 HCl
中文别名
英文别名	P505-15;PRT062607;PRT-062607;PRT 062607;
SMILES
化学名称
分子式	C19H23N9O.HCl	分子量	429.91
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL [1]. PRT318 and P505-15 effectively antagonize CLL cell survival after BCR triggering and in nurse-like cell-co-cultures. Moreover, they inhibit BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. in vivo: Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations.