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BAY 61-3606 dihydrochloride 结构式

BAY 61-3606 dihydrochloride

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货号 :BCP24726CAS号 :648903-57-5纯度:98%
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  • 基本信息与产品描述
CAS号 648903-57-5 货号 BCP24726
中文名 BAY 61-3606 dihydrochloride
英文名 BAY 61-3606 dihydrochloride
中文别名
英文别名 BAY 61-3606 2HCl;BAY 613606; BAY613606; BAY-613606;
SMILES
化学名称
分子式 C20H20Cl2N6O3 分子量 463.32
纯度 98% 配送 惯例下常温包邮
产品描述 BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. BAY 61-3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61-3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8.1 nM). B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes were also potently suppressed by BAY 61-3606.
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