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CAS号 | 575474-82-7 | 货号 | BCP20695 |
中文名 | R 112 | ||
英文名 | R 112 | ||
中文别名 | |||
英文别名 | R 112 (pharMaceutical);R112; R-112; | ||
SMILES | |||
化学名称 | |||
分子式 | C16H13FN4O2 | 分子量 | 312.3 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L). |
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