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CAS号 | 1613439-62-5 | 货号 | BCP48085 |
关联产品 | 1373615-35-0(PF-5274857) | ||
中文名 | PF-05274857 HCl | ||
英文名 | PF-05274857 HCl | ||
中文别名 | |||
英文别名 | PF-5274857 HCl; PF-5274857 hydrochloride;PF05274857 HCl;PF 05274857 HCl; PF-5274857 hydrochloride; | ||
SMILES | CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C.Cl | ||
化学名称 | |||
分子式 | C20H26Cl2N4O3S | 分子量 | 473.42 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant. |
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