SUVN-911 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP32917CAS号：2414674-71-6纯度：98%

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CAS号	2414674-71-6	货号	BCP32917
中文名	SUVN-911
英文名	SUVN-911
中文别名
英文别名	SUVN911;SUVN 911;
SMILES	C1C2CC2NC1COC3=CN=C(C=C3)Cl.Cl
化学名称
分子式	C11H14Cl2N2O	分子量	261.14
纯度	98%	配送	惯例下常温包邮
产品描述	SUVN-911 is a Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.SUVN-911 is a potent α4β2 receptor ligand with a Ki value of 1.5 nM. It showed >10 μM binding affinity toward the ganglionic α3β4 receptor apart from showing selectivity over 70 other targets. It is orally bioavailable and showed good brain penetration in rats. Marked antidepressant activity and dose-dependent receptor occupancy in rats support its potential therapeutic utility in the treatment of depression. It does not affect the locomotor activity at doses several folds higher than its efficacy dose. It is devoid of cardiovascular and gastrointestinal side effects. Successful long-term safety studies in animals and phase-1 evaluation in healthy humans for safety, tolerability, and pharmacokinetics paved the way for its further development.