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CAS号 | 917837-54-8 | 货号 | BCP35052 |
中文名 | CCMI | ||
英文名 | CCMI | ||
中文别名 | |||
英文别名 | AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; Anvylic-3288; UCI-4083; UCI4083; UCI 4083; | ||
SMILES | CC1=NOC(=C1)C(=CNC2=CC=C(C=C2)Cl)C(=O)NC3=CC=C(C=C3)Cl | ||
化学名称 | |||
分子式 | C19H15Cl2N3O2 | 分子量 | 388.25 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | CCMI is a first-in-class, orally available, small molecule, selective allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7 nAChR). AVL-3288 has shown preclinical efficacy in rat paradigms of attention and memory, including models of cognitive dysfunction1-3. AVL-3288 evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). AVL-3288 exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons. |
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